Table of Contents

Research Articles

1

Elucidating the Role of Auxin Gradient in Leaf Morphogenesis of Arabidopsis thaliana

Liu Mei-Hua, Arne Müller, Carlos J. Velázquez

Department of Botany, Peking University, China; Institute of Plant Sciences, University of Göttingen, Germany; Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia, Spain

Keywords: auxin, leaf morphogenesis, Arabidopsis thaliana, phytohormones, computational modeling, genetic mutants

The development of plant organs such as leaves is a complex process orchestrated by multiple phytohormones, among which auxin plays a critical role. This study aims to investigate the influence of aux...

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2

Functional Connectivity Alterations in Working Memory Networks Across Age Groups

Lena M. Schuster, Chen Ming-Hao, Adebayo Oluwaseun

Lena M. Schuster; Department of Cognitive Neuroscience, University of Freiburg, Germany; Chen Ming-Hao; Department of Biomedical Engineering, Tsinghua University, China; Adebayo Oluwaseun; Department of Neurology, University of Lagos, Nigeria

Keywords: functional connectivity, working memory, aging, default mode network, frontoparietal network, cognitive decline, fMRI

The neural basis of cognitive decline with aging remains a critical area of research within neuroscience. This study investigates the alterations in functional connectivity of brain networks associate...

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3

Integrating Sparse Data with Neural Networks for Enhanced Genomic Prediction Models

Felix J. Mühlberg, Mei-Li Zhang, Priya N. Iyer

Department of Computational Biology, University of Heidelberg, Germany; School of Bioinformatics, Tsinghua University, China; Department of Computer Science, Indian Institute of Technology Madras, India

Keywords: computational biology, machine learning, genomic prediction, neural networks, sparse data, convolutional neural networks, recurrent neural networks

The advancement of machine learning techniques offers significant potential in the field of computational biology, particularly in genomic prediction modeling. This study aims to integrate sparse geno...

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4

Functional Dynamics of Small Nuclear Ribonucleoproteins in Eukaryotic RNA Splicing

Sven Eriksson, Li Mei-Yun, Fatima Al-Mansouri

Department of Molecular Biosciences, Stockholm University, Sweden; Institute of Molecular Biology, Tsinghua University, Beijing, China; Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia

Keywords: small nuclear ribonucleoproteins, RNA splicing, spliceosome, cryo-electron microscopy, Saccharomyces cerevisiae, U1 snRNP

RNA processing, particularly the splicing of precursor mRNA, is a critical step in gene expression regulation. This study investigates the role of small nuclear ribonucleoproteins (snRNPs) in the spli...

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5

Deciphering the Molecular Orchestration of Lung Organogenesis in Zebrafish Models

Sven J. Muller, Priya Patel, Li Wei-Hong

Department of Developmental Biology, Max Planck Institute for Stem Cell Research, Germany; Department of Biological Sciences, Indian Institute of Science, India; School of Life Sciences, Peking University, China

Keywords: organogenesis, lung development, zebrafish, CRISPR/Cas9, Wnt signaling, Fgf signaling, transcription factors, regenerative medicine

Organogenesis is a critical phase of embryonic development whereby specific organs form from a relatively undifferentiated mass of cells. Our study focuses on elucidating the genetic and molecular pat...

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6

Advancements in mRNA-Lipid Nanoparticle Platforms for Next-Generation Vaccines

Matthias J. Neumann, Xiao Liu-Yang, Priya N. Kapoor

Department of Immunology, Charité – Universitätsmedizin Berlin, Germany; Institute of Biochemical Engineering, Tsinghua University, Beijing, China; Department of Biotechnology, Indian Institute of Technology, Bombay, India

Keywords: mRNA vaccines, lipid nanoparticle, immunogenicity, antigen expression, vaccine safety, rapid development

The rapid development of vaccines during the COVID-19 pandemic has highlighted the potential of mRNA-lipid nanoparticle (LNP) platforms in immunology. This study aims to explore the efficacy and safet...

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7

Deciphering Crosstalk Pathways in EGF-Induced Cell Signaling Networks

Lars van der Zwaal, Meera Srinivasan, Hu Zhi-Lin

Department of Molecular Cell Biology, Leiden University, Netherlands; Department of Biochemistry, Indian Institute of Science, Bangalore, India; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Keywords: EGF, cell signaling, phosphorylation, MAPK pathway, PI3K/AKT pathway, RAC1, GAB1, proteomics

Cell signaling via epidermal growth factor (EGF) is a critical process in regulating cellular proliferation, differentiation, and migration. The objective of this study was to elucidate the intricate ...

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