Vol. 20, Issue 1
Section 1
ID: Uh4nk
Hiroshi Masuda, Fatima El-Sayed, Kumiko Nishimura
Keywords: Department of Biophysics, University of Tokyo, Japan; Department of Molecular Biology, Cairo University, Egypt; Department of Structural Biology, Kyoto University, Japan
Protein folding is a fundamental process essential for cellular function, and its misregulation is linked to numerous diseases. This study investigates the influence of chaperone proteins on protein folding dynamics, seeking to provide insights into their mechanistic roles. We utilized a combination...
Vol. 20, Issue 1
Section 1
ID: e79Vd
Hiroshi Nakamura, Priya S. Menon, Ahmed El-Mansouri
Keywords: Department of Virology, University of Tokyo, Japan; Department of Microbial Genetics, Indian Institute of Science, Bangalore, India; Department of Molecular Biology, Cairo University, Egypt
The rapid evolution of viruses presents significant challenges to public health, primarily due to their ability to adapt quickly via mutation. This study investigates the adaptive mechanisms within RNA viruses, focusing on mutation dynamics and their impact on virulence and transmissibility. Utilizi...
Vol. 20, Issue 1
Section 1
ID: ckdLx
Lars M. Kaufmann, Min-Jae Lee, Sofia R. Hernandez
Keywords: Department of Neuroscience, Humboldt University of Berlin, Germany; Department of Brain and Cognitive Sciences, Seoul National University, South Korea; Instituto de Neurociencias, Universidad Nacional Autónoma de México, Mexico
Understanding the dynamics of neural networks involved in cognitive processing is critical for advancing our knowledge of brain function. This study aims to employ advanced functional magnetic resonance imaging (fMRI) techniques to characterize the temporal and spatial patterns of neural activity as...
Vol. 20, Issue 1
Section 1
ID: a4ULT
Hans-Peter Müller, Li Ming-Hu, Priya N. Iyer
Keywords: Department of Structural Biology, Max Planck Institute of Biochemistry, Germany; Department of Biochemistry, Peking University, China; School of Life Sciences, University of Hyderabad, India
The allosteric regulation of AMP-activated protein kinase (AMPK) plays a pivotal role in cellular energy homeostasis, making it a critical target for therapeutic intervention in metabolic disorders. Despite extensive study, the detailed structural mechanisms underlying its allosteric modulation rema...
Vol. 20, Issue 1
Section 1
ID: As87s
Levent Ozdemir, Hiroshi Nakamura, Aditi Raghavan
Keywords: Department of Computational Biology, Bogazici University, Istanbul, Turkey; Department of Bioinformatics, Kyoto University, Kyoto, Japan; Department of Systems Biology, Indian Institute of Science, Bangalore, India
The rapid advancement in genomic technologies has generated vast amounts of data, necessitating sophisticated computational techniques for analysis. This study aims to enhance predictive modeling in genomic studies through integrative network analysis. We developed a computational framework that inc...
Vol. 20, Issue 1
Section 1
ID: mw5Jm
Hans-Jürgen Müller, Kim Soo-Jin, Leila Haddad
Keywords: Department of Immunology, Charité - Universitätsmedizin Berlin, Germany; Department of Immunology, Seoul National University College of Medicine, South Korea; Department of Immunology, American University of Beirut, Lebanon
Autoimmune diseases are characterized by the immune system's aberrant response to self-antigens, leading to tissue damage and chronic inflammation. Despite extensive research, the precise mechanisms underlying self-antigen recognition remain poorly understood. This study aims to delineate the pathwa...
Vol. 20, Issue 1
Section 1
ID: 26FMM
Katrin E. Müller, Yuko Sato, Andrés M. Pérez
Keywords: Institute of Plant Sciences, University of Freiburg, Germany; Department of Biological Sciences, University of Tokyo, Japan; Departamento de BiologÃa, Universidad Nacional de Córdoba, Argentina
The complexity of plant immunity lies in its ability to integrate various signaling pathways to mount an effective defense response. This study aims to dissect the cross-talk mechanisms among key signaling pathways in plant immunity using Arabidopsis thaliana as a model organism. We employed a combi...