Vol. 20, Issue 7
Section 1
ID: bZSMM
Katrin M. Svensson, Hiroshi Nakamura, Nneka A. Okoro
Keywords: Department of Computational Biology, Uppsala University, Sweden; Institute of Integrative Bioinformatics, University of Tokyo, Japan; Department of Biostatistics, University of Nigeria, Nsukka, Nigeria
The integration of machine learning algorithms into computational biology has transformed the way cellular dynamics are understood and modeled. This study aims to develop a robust predictive framework for cellular interactions using an integrative machine learning approach. We employed a combination...
Vol. 20, Issue 7
Section 1
ID: 37qSB
Heinrich J. Vogel, Mei-Ling Zhang, Pedro N. Oliveira
Keywords: Department of Developmental Biology, University of Freiburg, Germany; Department of Biological Sciences, Tsinghua University, Beijing, China; Departamento de Biologia Celular, Universidade de São Paulo, Brazil
Morphogenesis, the biological process that causes an organism to develop its shape, remains a focal point of developmental biology. This study explores the cellular and molecular mechanisms underlying vertebrate limb development, focusing on the dynamic interactions between signaling pathways and ce...
Vol. 20, Issue 7
Section 1
ID: YmXUN
Anika M. Voigt, Hiroshi Nakamura, Nneka Okafor
Keywords: Department of Immunology, University of Freiburg, Germany; Department of Molecular Immunology, Kyoto University, Japan; Department of Medical Sciences, University of Nigeria, Nsukka
The immune system's response to viral infections involves a complex interplay between innate and adaptive immunity. This study aims to elucidate the mechanisms through which these two arms of the immune system communicate during the early stages of a viral infection. Using a murine model of influenz...
Vol. 20, Issue 7
Section 1
ID: Pk8up
Hans M. Vogler, Li Mei-Ping, Tarun N. Patel
Keywords: Department of Plant Sciences, University of Hohenheim, Germany; Institute of Crop Sciences, Zhejiang University, China; Department of Agricultural Biotechnology, Indian Institute of Science, Bangalore, India
Climate change poses significant challenges to global agriculture, particularly in arid and semi-arid regions. To address these challenges, our study focuses on enhancing the drought resilience of wheat (Triticum aestivum). We employed an integrative approach combining genomic selection and phenotyp...
Vol. 20, Issue 7
Section 1
ID: J5JVG
Julian M. Schneider, Nisha Patel, Yang Li-Hua
Keywords: Department of Cell Biology, University of Heidelberg, Germany; Department of Molecular Biology, Indian Institute of Science, Bangalore, India; Institute of Cellular and Molecular Biosciences, Peking University, China
Organelle dynamics play a crucial role in maintaining cellular homeostasis, with mitochondria and peroxisomes being central to metabolic regulation and reactive oxygen species detoxification. This study aims to elucidate the dynamic interactions between mitochondrial and peroxisomal networks within ...
Vol. 20, Issue 7
Section 1
ID: j66LZ
Heike M. Bernhardt, Chen Ming-Hua, Arjun V. Patel
Keywords: Department of Biochemistry, University of Heidelberg, Germany; Department of Chemical Biology, Tsinghua University, China; Molecular Biology Division, Indian Institute of Science, India
Proteomics is an essential tool in biochemistry, offering insights into protein function and interaction. Our study aims to advance proteomic profiling by exploring post-translational modifications (PTMs) across varying cellular environments. We employed a combination of mass spectrometry and bioinf...
Vol. 20, Issue 7
Section 1
ID: cLmxb
Lars E. Neumann, Anand Kumar Singh, Mei-Ling Zhang
Keywords: Department of Physics, University of Freiburg, Germany; Department of Biophysics, Indian Institute of Science, Bangalore, India; School of Life Sciences, Fudan University, China
The intricate process of protein folding is pivotal to understanding cellular mechanisms and disease pathologies. In this study, we aim to elucidate the folding pathways of proteins by employing single-molecule Förster Resonance Energy Transfer (smFRET). This technique allows for real-time observat...