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Found 4 articles for "Peking University"
The allosteric regulation of AMP-activated protein kinase (AMPK) plays a pivotal role in cellular energy homeostasis, making it a critical target for therapeutic intervention in metabolic disorders. Despite extensive study, the detailed structural me...
Understanding the mechanisms of protein folding remains a central challenge in biophysics. This study focuses on the kinetic pathways and thermodynamic stability in the folding of small globular proteins. We aimed to elucidate the interplay between f...
Gene therapy has emerged as a promising approach for the treatment of monogenic disorders, leveraging advances in genome editing technologies. This study aims to evaluate the efficacy and safety of CRISPR-Cas9 mediated gene therapy in correcting gene...
Objective: RNA interference (RNAi) is a widely used mechanism to knock down target gene expression. Successful application of RNAi requires efficient delivery of siRNA into cells. This study demonstrates an efficient and specific knockdown of stim1, ...